Microparticles as biomarkers of osteonecrosis of the hip in sickle cell disease.
Br J Haematol
; 168(1): 135-8, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25196812
ABSTRACT
Osteonecrosis of the femoral head (ONFH) is a common complication of sickle cell disease (SCD). To examine the association between microparticles and ONFH in SCD, we compared plasma microparticle levels in 20 patients with and without ONFH. Microparticles were quantified using nanoparticle tracking analysis and found to be 2·3-fold higher in patients with ONFH compared to patients without ONFH, and 2·5-fold higher than in healthy controls. These results suggest that microparticles may be a clinically useful biomarker of ONFH in SCD. Further investigations are needed to determine the functional relevance of microparticles in the pathogenesis of ONFH in SCD.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Micropartículas Derivadas de Células
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Necrose da Cabeça do Fêmur
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Anemia Falciforme
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article