[Experimental study on relationship between pungent-hot herb property express and calmodulin].
Zhongguo Zhong Yao Za Zhi
; 39(5): 873-8, 2014 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-25204182
ABSTRACT
OBJECTIVE:
To explain the essence of pungent-hot herb property express according to in vivo and in vitro studies on its effect on calmodulin on the base of the observation of the adjustment in hypothalamic-pituitary-gonad axis functions of Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex in rats under the state of yang deficiency.METHOD:
The yang-deficient model was duplicated by intramuscularly injecting hydrocortisone sodium succinate powder injection. After the intervention with Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex and bitter-cold herb Phellodendri Chinensis Cortex for seven days, TSH, T3, T4, 17-OHCS, COR, T, E2 of hypothalamus-pituitary-target gland axis and other relevant indexes were detected. The calmodulin expression in livers and L02 cells cultured in vitro was detected by using Western blot.RESULT:
Pungent-hot herbs Aconiti Lateralis Radix Praeparata, Curculiginis Rhizoma, Cinnamomi Cortex can significantly correct indicators of hypothalamic-pituitary-gonad axis and calmodulin, whereas the bitter-cold herb Phellodendri Chinensis Cortex showed no obvious effect.CONCLUSION:
The pungent-hot herb property expression may be closely related to calmodulin.
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Base de dados:
MEDLINE
Assunto principal:
Calmodulina
/
Medicamentos de Ervas Chinesas
/
Deficiência da Energia Yang
/
Gônadas
/
Fígado
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article