The role of gene regulatory factors in the evolutionary history of humans.
Curr Opin Genet Dev
; 29: 60-7, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25215414
ABSTRACT
Deciphering the molecular basis of how modern human phenotypes have evolved is one of the most fascinating challenges in biology. Here, we will focus on the roles of gene regulatory factors (GRFs), in particular transcription factors (TFs) and long non-coding RNAs (lncRNAs) during human evolution. We will present examples of TFs and lncRNAs that have changed or show signs of positive selection in humans compared to chimpanzees, in modern humans compared to archaic humans, or within modern human populations. On the basis of current knowledge about the functions of these GRF genes, we speculate that they have been involved in speciation as well as in shaping phenotypes such as brain functions, skeletal morphology, and metabolic processes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
Fatores de Transcrição
/
Evolução Molecular
/
RNA Longo não Codificante
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article