SnapShot: FMRP mRNA targets and diseases.

Pasciuto, Emanuela; Bagni, Claudia

Pasciuto, Emanuela; Bagni, Claudia.

Afiliação

Pasciuto E; VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, 3000 Leuven, Belgium.
Bagni C; VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases (LIND), KU Leuven, 3000 Leuven, Belgium; Department of Biomedicine and Prevention, University of Rome "Tor Vergata," 00133 Rome, Italy.

Cell ; 158(6): 1446-1446.e1, 2014 Sep 11.

Article em En | MEDLINE | ID: mdl-25215498

RESUMO

FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases with which they have been associated.

Assuntos

Encefalopatias/genética; Proteína do X Frágil da Deficiência Intelectual/metabolismo; Transtornos Mentais/genética; RNA Mensageiro/metabolismo; Animais; Encefalopatias/metabolismo; Humanos; Transtornos Mentais/metabolismo; Neoplasias/genética; Neoplasias/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encefalopatias / RNA Mensageiro / Proteína do X Frágil da Deficiência Intelectual / Transtornos Mentais Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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