Regulation of local steroidogenesis in the brain and in prostate cancer: lessons learned from interdisciplinary collaboration.
Front Neuroendocrinol
; 36: 108-29, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25223867
ABSTRACT
Sex steroids play critical roles in the regulation of the brain and many other organs. Traditionally, researchers have focused on sex steroid signaling that involves travel from the gonads via the circulation to intracellular receptors in target tissues. This classic concept has been challenged, however, by the growing number of cases in which steroids are synthesized locally and act locally within diverse tissues. For example, the brain and prostate carcinoma were previously considered targets of gonadal sex steroids, but under certain circumstances, these tissues can upregulate their steroidogenic potential, particularly when circulating sex steroid concentrations are low. We review some of the similarities and differences between local sex steroid synthesis in the brain and prostate cancer. We also share five lessons that we have learned during the course of our interdisciplinary collaboration, which brought together neuroendocrinologists and cancer biologists. These lessons have important implications for future research in both fields.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Hormônios Esteroides Gonadais
/
Encéfalo
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article