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In vitro susceptibility of Mycobacterium tuberculosis isolates to an oral carbapenem alone or in combination with ß-lactamase inhibitors.
Horita, Yasuhiro; Maeda, Shinji; Kazumi, Yuko; Doi, Norio.
Afiliação
  • Horita Y; Department of Pathophysiology and Host Defense, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
  • Maeda S; Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
  • Kazumi Y; Department of Mycobacterium Reference and Research, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan.
  • Doi N; Department of Pathophysiology and Host Defense, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Matsuyama, Kiyose, Tokyo, Japan ndoi@jata.or.jp.
Antimicrob Agents Chemother ; 58(11): 7010-4, 2014 Nov.
Article em En | MEDLINE | ID: mdl-25224000
We evaluated the antituberculosis (anti-TB) activity of five ß-lactams alone or in combination with ß-lactamase inhibitors against 41 clinical isolates of Mycobacterium tuberculosis, including multidrug-resistant and extensively drug-resistant strains. Of those, tebipenem, an oral carbapenem, showed the most potent anti-TB activity against clinical isolates, with a MIC range of 0.125 to 8 µg/ml, which is achievable in the human blood. More importantly, in the presence of clavulanate, MIC values of tebipenem declined to 2 µg/ml or less.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbapenêmicos / Inibidores de beta-Lactamases / Mycobacterium tuberculosis / Antituberculosos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carbapenêmicos / Inibidores de beta-Lactamases / Mycobacterium tuberculosis / Antituberculosos Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article