Design of anticoagulant surfaces based on cellulose nanocrystals.
Chem Commun (Camb)
; 50(86): 13070-2, 2014 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-25225660
ABSTRACT
The anticoagulant activity of surfaces decorated with cellulose nanocrystals (CNCs) prepared via sulfuric acid hydrolysis, is explored. Such surfaces bear a high amount of negatively charged sulfate groups, which mimic the naturally occurring anticoagulant heparin in terms of charge density. It is demonstrated that CNC decorated surfaces significantly enhance the coagulation times of blood plasma and whole blood as proven by QCM-D and simple clotting tests.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Celulose
/
Nanopartículas
/
Anticoagulantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article