New posology of potassium iodide for the treatment of cutaneous sporotrichosis: study of efficacy and safety in 102 patients.
J Eur Acad Dermatol Venereol
; 29(4): 719-24, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25229626
ABSTRACT
BACKGROUND:
The first therapeutic choice for the treatment of cutaneous sporotrichosis is oral itraconazole; however, the increase in cases of zoonotic transmission outbreak necessitates a search for effective and safe treatment alternatives.OBJECTIVE:
To evaluate a new potassium iodide (KI) posology as an alternative for the treatment of limited cutaneous forms of sporotrichosis.METHODS:
One hundred and two patients with sporotrichosis diagnosed by isolation of Sporothrix sp. were included and were divided into 2 groups that received different doses of KI group A received the conventional dose, and group B received the reduced dose. The cure criteria were based on clinical and serological data.RESULTS:
Seventy-nine patients (77.4%) reached clinical cure 70.6% and 84.3% of groups A and B respectively. Sixteen patients (15.6%) were lost during follow-up, and seven changed drug therapy five in group A and two in group B. The incidence of adverse events was similar for both groups (64.7%) predominantly metallic taste (44%), followed by mild gastrointestinal intolerance and acneiform eruption (10.7% each). No serious adverse events occurred, and there were no recurrences. Analysis of the results showed no statistically significant difference between groups (P = 0.9255). The improvement in serologic titres was significant in both treatment groups.CONCLUSION:
Through statistical analysis, the usual posology was not shown to be superior to the one proposed in this study. Serology for sporotrichosis may be used as a valuable tool in the clinical monitoring of these patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Iodeto de Potássio
/
Esporotricose
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Antifúngicos
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article