IL-1ß induces IL-6 production in retinal Müller cells predominantly through the activation of p38 MAPK/NF-&#954;B signaling pathway.

Liu, Xiufen; Ye, Fei; Xiong, Huabao; Hu, Dan-Ning; Limb, G Astrid; Xie, Tian; Peng, Liang; Zhang, Pili; Wei, Yi; Zhang, Wiley; Wang, Juan; Wu, Hongwei; Lee, Peng; Song, E; Zhang, David Y

IL-1ß induces IL-6 production in retinal Müller cells predominantly through the activation of p38 MAPK/NF-κB signaling pathway.

Liu, Xiufen; Ye, Fei; Xiong, Huabao; Hu, Dan-Ning; Limb, G Astrid; Xie, Tian; Peng, Liang; Zhang, Pili; Wei, Yi; Zhang, Wiley; Wang, Juan; Wu, Hongwei; Lee, Peng; Song, E; Zhang, David Y.

Afiliação

Liu X; Department of Ophthalmology, The First Hospital, Jilin University, Xinmin Street 71, Changchun, Jilin 130021, China.
Ye F; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Xiong H; Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Hu DN; Tissue Culture Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.
Limb GA; Division of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology, Bath Street, London EC1V 9EL, UK.
Xie T; Department of neurosurgery, The People×³s Hospital of Jilin Province, Changchun, Jilin 130021.
Peng L; Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Zhang P; Department of Medicine, Endocrinology, Diabetes and Bone Disease, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wei Y; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Zhang W; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wang J; Department of Medicine, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Wu H; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Lee P; Departments of Pathology, Urology, NYU Cancer Institute, New York Harbor Healthcare System, New York University, School of Medicine, New York, NY 10010, USA.
Song E; Department of Ophthalmology, The First Hospital, Jilin University, Xinmin Street 71, Changchun, Jilin 130021, China; The Ophthalmology Hospital Affiliated Suzhou University, Jiangsu, Suzhou 215021, China. Electronic address: songe23@126.com.
Zhang DY; Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: david.zhang@mssm.edu.

Exp Cell Res ; 331(1): 223-231, 2015 Feb 01.

Article em En | MEDLINE | ID: mdl-25239226

Assuntos

Interleucina-1beta/farmacologia; Interleucina-6/genética; NF-kappa B/metabolismo; Retina/efeitos dos fármacos; Retina/metabolismo; Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo; Western Blotting; Proliferação de Células; Células Cultivadas; Humanos; Interleucina-6/metabolismo; Luciferases/metabolismo; NF-kappa B/genética; Fosforilação/efeitos dos fármacos; Regiões Promotoras Genéticas/genética; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Retina/citologia; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais/efeitos dos fármacos; Proteínas Quinases p38 Ativadas por Mitógeno/genética

Palavras-chave

Interleukin 1ß (IL-1ß); Interleukin 6 (IL-6); Müller cells; NF-κB; Promoter; p38 MAPK

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Retina / NF-kappa B / Interleucina-6 / Proteínas Quinases p38 Ativadas por Mitógeno / Interleucina-1beta Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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