First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids.

ABSTRACT

OBJECTIVE: To study the pregnancy rate after ulipristal acetate (UPA) therapy for fibroids. DESIGN: Retrospective analysis of a series of 52 patients prospectively included in the PGL4001 (ulipristal acetate) Efficacy Assessment in Reduction of Symptoms Due to Uterine Leiomyomata (PEARL) II and III trials. SETTING: Academic hospital. PATIENT(S) Among the 52 patients, 21 wished to conceive upon treatment completion. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Pregnancy rate and live birth rate. RESULT(S) Twenty-one patients attempted to get pregnant, among whom 15 (71%) succeeded, totaling 18 pregnancies. Among these 18 pregnancies, 12 resulted in the birth of 13 healthy babies and 6 ended in early miscarriage. No regrowth of fibroids was observed during pregnancy. CONCLUSION(S) We report the first series of pregnancies achieved after UPA treatment. Our data confirm a sustained long-term effect after UPA therapy.