An abnormally glycosylated isoform of erythropoietin in hemangioblastoma is associated with polycythemia.
Clin Chim Acta
; 438: 304-6, 2015 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-25245675
ABSTRACT
BACKGROUND:
Hemangioblastomas express erythropoietin and the patients often present with polycythemia.METHODS:
Serum erythropoietin was measured using a commercial immunoassay, a functional erythropoietin assay and iso-electric focusing.RESULTS:
Despite the polycythemia, serum erythropoietin remained low, while a functional erythropoietin-assay showed a 4-5 higher activity in serum compared to the immunoassay. Iso-electric focusing of serum erythropoietin indicated overrepresentation of highly sialylated erythropoietin isoforms produced by the tumor. As a result, altered affinity of the monoclonal antibody used in the immunoassay for the hypersialylated isoforms was suggested.CONCLUSION:
Analysis of erythropoietin isoforms may be helpful in distinguishing the ectopic erythropoietin isoforms from normally glycosylated erythropoietin.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Policitemia
/
Eritropoetina
/
Neoplasias do Sistema Nervoso Central
/
Artefatos
/
Hemangioblastoma
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article