The taumycin A macrocycle: asymmetric total synthesis and revision of relative stereochemistry.
Org Lett
; 16(19): 5196-9, 2014 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-25248034
ABSTRACT
The first asymmetric total synthesis and revision of the relative configuration of the 12-membered taumycin A macrocycle is described. Key to the success of this work was a novel α-keto ketene macrocyclization that provided an efficient means by which to access two diastereomers of the desired macrolide without the need to employ additional coupling agents or unnecessary oxidation state adjustments.
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Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
/
Depsipeptídeos
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article