Stable small quantum dots for synaptic receptor tracking on live neurons.
Angew Chem Int Ed Engl
; 53(46): 12484-8, 2014 Nov 10.
Article
em En
| MEDLINE
| ID: mdl-25255882
ABSTRACT
We developed a coating method to produce functionalized small quantum dots (sQDs), about 9â
nm in diameter, that were stable for over a month. We made sQDs in four emission wavelengths, from 527 to 655â
nm and with different functional groups. AMPA receptors on live neurons were labeled with sQDs and postsynaptic density proteins were visualized with super-resolution microscopy. Their diffusion behavior indicates that sQDs access the synaptic clefts significantly more often than commercial QDs.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de AMPA
/
Pontos Quânticos
/
Corantes Fluorescentes
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article