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EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data.
Winkler, Thomas W; Kutalik, Zoltan; Gorski, Mathias; Lottaz, Claudio; Kronenberg, Florian; Heid, Iris M.
Afiliação
  • Winkler TW; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
  • Kutalik Z; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
  • Gorski M; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
  • Lottaz C; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
  • Kronenberg F; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
  • Heid IM; Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Sw
Bioinformatics ; 31(2): 259-61, 2015 Jan 15.
Article em En | MEDLINE | ID: mdl-25260699
ABSTRACT
UNLABELLED The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i) statistical methods to test and account for between-strata difference as a means to tackle gene-strata interaction effects and (ii) extended graphical features tailored for stratified GWAMA results. The software provides further features also suitable for general GWAMAs including functions to annotate, exclude or highlight specific loci in plots or to extract independent subsets of loci from genome-wide datasets. It is freely available and includes a user-friendly scripting interface that simplifies data handling and allows for combining statistical and graphical functions in a flexible fashion.

AVAILABILITY:

EasyStrata is available for free (under the GNU General Public License v3) from our Web site www.genepi-regensburg.de/easystrata and from the CRAN R package repository cran.r-project.org/web/packages/EasyStrata/. SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Gráficos por Computador / Software / Genoma Humano / Metanálise como Assunto / Biologia Computacional / Estudo de Associação Genômica Ampla Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article
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Texto completo: 1 Eixos temáticos: Pesquisa_clinica Base de dados: MEDLINE Assunto principal: Gráficos por Computador / Software / Genoma Humano / Metanálise como Assunto / Biologia Computacional / Estudo de Associação Genômica Ampla Tipo de estudo: Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article