Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties.
Int J Hyg Environ Health
; 218(1): 91-8, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25277764
ABSTRACT
The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bifenilos Policlorados
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Sangue Fetal
Tipo de estudo:
Diagnostic_studies
Limite:
Female
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Humans
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Newborn
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Pregnancy
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article