Elevation of proteasomal substrate levels sensitizes cells to apoptosis induced by inhibition of proteasomal deubiquitinases.

Sun, Chao; Roboti, Peristera; Puumalainen, Marjo-Riitta; Fryknäs, Mårten; Wang, Xin; D'Arcy, Padraig; Hult, Malin; High, Stephen; Linder, Stig; Swanton, Eileithyia

Sun, Chao; Roboti, Peristera; Puumalainen, Marjo-Riitta; Fryknäs, Mårten; Wang, Xin; D'Arcy, Padraig; Hult, Malin; High, Stephen; Linder, Stig; Swanton, Eileithyia.

Afiliação

Sun C; Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
Roboti P; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Puumalainen MR; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Fryknäs M; Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University, Uppsala, Sweden.
Wang X; Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
D'Arcy P; Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
Hult M; Center for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
High S; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.
Linder S; Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska Institute, Stockholm, Sweden.
Swanton E; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

PLoS One ; 9(10): e108839, 2014.

Article em En | MEDLINE | ID: mdl-25286379

Assuntos

Apoptose; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteases Específicas de Ubiquitina/antagonistas & inibidores; Cisteína/metabolismo; Cisteína/farmacologia; Citoproteção/efeitos dos fármacos; Retículo Endoplasmático/efeitos dos fármacos; Retículo Endoplasmático/metabolismo; Células HCT116; Células HeLa; Humanos; Peso Molecular; Piperidonas/farmacologia; Poliubiquitina/metabolismo; Inibidores de Proteassoma/farmacologia; Transporte Proteico/efeitos dos fármacos; Proteólise/efeitos dos fármacos; Saposinas/metabolismo; Especificidade por Substrato/efeitos dos fármacos; Proteases Específicas de Ubiquitina/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Complexo de Endopeptidases do Proteassoma / Proteases Específicas de Ubiquitina Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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