Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice.

Xu, Guilian; Ayers, Jacob I; Roberts, Brittany L; Brown, Hilda; Fromholt, Susan; Green, Cameron; Borchelt, David R

Xu, Guilian; Ayers, Jacob I; Roberts, Brittany L; Brown, Hilda; Fromholt, Susan; Green, Cameron; Borchelt, David R.

Afiliação

Xu G; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center and.
Ayers JI; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease.
Roberts BL; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease.
Brown H; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center and.
Fromholt S; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center and.
Green C; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease.
Borchelt DR; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center and McKnight Brain Institute, University of Florida, PO Box 100159 Center Drive, Gainesville, FL 32610, USA drb1@ufl.edu borchelt@mbi.ufl.edu.

Hum Mol Genet ; 24(4): 1019-35, 2015 Feb 15.

Article em En | MEDLINE | ID: mdl-25305079

Assuntos

Mutação; Superóxido Dismutase/genética; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Esclerose Lateral Amiotrófica/mortalidade; Animais; Linhagem Celular; Modelos Animais de Doenças; Feminino; Expressão Gênica; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Neurônios Motores/metabolismo; Proteínas Mutantes/metabolismo; Ligação Proteica; Multimerização Proteica; Transporte Proteico; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Superóxido Dismutase/química; Superóxido Dismutase/metabolismo; Superóxido Dismutase-1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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