Polygonum cuspidatum extracts as bioactive antioxidaion, anti-tyrosinase, immune stimulation and anticancer agents.
J Biosci Bioeng
; 119(4): 464-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25311751
ABSTRACT
In our study, it was applied for the technology of supercritical fluid carbon dioxide extraction to achieve biological constitutes from a Taiwan native plant, Polygonum cuspidatum. We developed bioactive effects of P. cuspidatum extracts via multiple examinations that established bio-purposes at a range of dosage ranges. The research of P. cuspidatum extracts indicated that they possessed anti-oxidative properties on radical-scavenging abilities, reducing activities and metal chelating powers in dose-dependant manners. The extracts also had minor in vitro mushroom tyrosinase suppression and decreased cellular tyrosinase activities and melanin production in B16-F10 cells. Immunologically, P. cuspidatum extracts enhanced the release of tumor necrosis factor α (TNF-α) induced by THP-1 macrophage cell line. In addition, the cell proliferation showed anti-proliferation in dose-dependent manner on human skin melanoma cells, A375 and A375.S2, of the extracts suggesting biological constitutes employed the anti-cancer possessions. This is the first statement presenting bioactivities on P. cuspidatum extracts including anti-oxidation, immune stimulation, anti-tyrosinase and anti-melanoma as far as we know.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Monofenol Mono-Oxigenase
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Fallopia japonica
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Imunidade
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Melanoma
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Antineoplásicos
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article