Enhancement of bone regeneration with the combination of platelet-rich fibrin and synthetic graft.
J Craniofac Surg
; 25(6): 2164-8, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25318438
ABSTRACT
INTRODUCTION:
Platelet-rich fibrin (PRF) is a relatively new developed platelet concentrate with several benefits over platelet-rich plasma. The aim of this study was to compare healing properties of PRF and its combination with a ceramic synthetic material (graft) composed of hydroxyapatite and b-tricalcium phosphate in an animal model.METHODS:
A bone deficit was surgically created in each femoral condyle of 15 New Zealand white rabbits. In each animal, 1 limb had (a) PRF only and the other (b) PRF plus synthetic graft material randomly implanted. Experimental animals were killed 3 months postoperatively. Histological and radiological examinations were made by means of computed tomography and peripheral quantitative computed tomography.RESULTS:
Mean density of the healed bone was statistically significantly greater when synthetic material was used (P < 0.0005). Moreover, combination of PRF with the synthetic material resulted in more cortical and subcortical bone formation (P = 0.038 and P = 0.037, respectively).CONCLUSIONS:
The addition of the ceramic material significantly increased the formation of new bone, providing a better substrate for bone regeneration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Regeneração Óssea
/
Fibrina
/
Substitutos Ósseos
/
Hidroxiapatitas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article