Increase in visceral fat per se does not induce insulin resistance in the canine model.
Obesity (Silver Spring)
; 23(1): 105-11, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25322680
ABSTRACT
OBJECTIVES:
To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance.METHODS:
Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI ) and the euglycemic hyperinsulinemic clamp (SICLAMP ). Changes in abdominal fat were monitored by magnetic resonance. All assessments were determined before (Wk0) and 2 weeks (Wk2) after denervation. Data are medians (upper and lower interquartile).RESULTS:
Denervation of omental fat resulted in increased percentage (and content) of visceral fat [Wk0 10.2% (8.5-11.4); Wk2 12.4% (10.4-13.6); P < 0.01]. Abdominal subcutaneous fat remained unchanged. However, no changes were found in SI [Wk0 4.7 (mU/l)(-1) min(-1) (3.1-8.8); Wk2 5.3 (mU/l)(-1) min(-1) (4.5-7.2); P = 0.59] or SICLAMP [Wk0 42.0 × 10(-4) dl kg(-1) min(-1) (mU/l)(-1) (41.0-51.0); Wk2 40.0 × 10(-4) dl kg(-1) min(-1) (mU/l) (-1) (34.0-52.0); P = 0.67].CONCLUSIONS:
Despite a selective increase in visceral adiposity in dogs, insulin sensitivity in vivo did not change, which argues against the concept that accumulation of visceral adipose tissue contributes to insulin resistance.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência à Insulina
/
Gordura Intra-Abdominal
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article