The application of 1,8-cineole, a terpenoid oxide present in medicinal plants, inhibits castor oil-induced diarrhea in rats.
Pharm Biol
; 53(4): 594-9, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25327386
ABSTRACT
CONTEXT 1,8-Cineole, a terpene, characterized as a major constituent occurring in the essential oils of several aromatic plants. It is widely used in pharmaceutical industry, as a food additive and for culinary purposes. OBJECTIVE:
This study investigates the inhibitory effect of 1,8-cineole on transit time and diarrhea in animal models. MATERIALS ANDMETHODS:
Acute toxicity and lethality of 1-8-cineole was determined by Lork's guidelines. The antidiarrheal effect of 1,8-cineole was investigated by determining the intestinal transit and enterpooling in rats. In all experiments, different doses of 1,8-cineole (20-120 mg/kg), atropine, and loperamide were administered orally.RESULTS:
The LD50 of 1,8-cineole for oral administration was estimated to be 1280 mg/kg. 1,8-Cineole (20-120 mg/kg) did not show a significant decrease in small intestine transit (p > 0.05); however, the highest dose displayed a significant decrease in comparison with atropine (p < 0.05). This substance decreased the peristaltic index value to 68 ± 0.36% at a dose of 120 mg/kg compared with the control group (85.22 ± 4.31%) in the castor oil transit test. 1,8-Cineole significantly delayed the onset of diarrhea to -142.33 ± 6.08 min at 120 mg/kg, while the time was 103.66 ± 20.73 min for the control and >240 min for the loperamide. Moreover, 1,8-cineole significantly decreased intestinal fluid accumulation (p < 0.05).CONCLUSIONS:
This study demonstrated antispasmodic and antisecretory activities of 1,8-cineole and rationalized the traditional use of the plant containing various levels of this terpene in the treatment of gastrointestinal complains such as diarrhea.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Óleo de Rícino
/
Cicloexanóis
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Monoterpenos
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Diarreia
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Antidiarreicos
Tipo de estudo:
Guideline
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article