[The effect of oversized occluder on endothelialization after percutaneous closure of experimental atrial septal defect in dogs].
Zhonghua Xin Xue Guan Bing Za Zhi
; 42(7): 557-60, 2014 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-25327596
ABSTRACT
OBJECTIVE:
To observe the effect of oversized occluder on endothelialization post percutaneous closure of experimental atrial septal defect (ASD) in dogs.METHODS:
ASD was established with the help of transthoracic echocardiography in 18 dogs. ASD size was (6.0 ± 0.2) mm. Dogs were randomly divided into normal size group (implanted with 8 mm occlude, n = 9) and oversized group (implanted with 12 mm occluder, n = 9). Dogs were randomly killed at 3, 6 and 14 months after percutaneous closure. The endothelialization process on device surface was observed by scanning electron microscope.RESULTS:
Four animals died around 1 month post procedure. Microscopic sections from normal group showed nearly complete endothelialization at 3 months after device implantation and complete endothelialization at 6 and 14 months after device implantation. While microscopic sections showed lack of endothelialization at 3 months post implantation, nearly endothelialization at 6 months, and complete endothelialization at 14 months after device implantation in oversized group.CONCLUSION:
Incomplete endothelialization of occluder surface is observed at 6 months after implantation of an oversized ASD occluder device in this model.
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Base de dados:
MEDLINE
Assunto principal:
Dispositivo para Oclusão Septal
/
Intervenção Coronária Percutânea
/
Comunicação Interatrial
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article