Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10.
Eur J Immunol
; 45(1): 180-91, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25329858
ABSTRACT
Forkhead box P3 (Foxp3)(+) regulatory T (Treg) cells maintain the immune tolerance and prevent inflammatory responses in the periphery. However, the presence of Treg cells in the CNS under steady state has not been studied. Here, for the first time, we show a substantial TCRαß (+) CD4(+) Foxp3(+) T-cell population (cerebral Treg cells) in the rat cerebrum, constituting more than 15% of the cerebral CD4(+) T-cell compartment. Cerebral Treg cells showed an activated/memory phenotype and expressed many Treg-cell signature genes at higher levels than peripheral Treg cells. Consistent with their activated/memory phenotype, cerebral Treg cells robustly restrained the LPS-induced inflammatory responses of brain microglia/macrophages, suggesting a role in maintaining the cerebral homeostasis by inhibiting the neuroinflammation. In addition, brain astrocytes were the helper cells that sustained Foxp3 expression in Treg cells through IL-2/STAT5 signaling, showing that the interaction between astrocytes and Treg cells contributes to the maintenance of Treg-cell identity in the brain. Taken together, our work represents the first study to characterize the phenotypic and functional features of Treg cells in the rat cerebrum. Our data have provided a novel insight for the contribution of Treg cells to the immunosurveillance and immunomodulation in the cerebrum under steady state.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Astrócitos
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Interleucina-10
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Linfócitos T Reguladores
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Encefalite
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Cérebro
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article