Protein O-GlcNAcylation and cardiovascular (patho)physiology.
J Biol Chem
; 289(50): 34449-56, 2014 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-25336635
Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Acetilglucosamina
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Sistema Cardiovascular
/
Proteínas
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article