Molecular-dynamics-simulation-driven design of a protease-responsive probe for in-vivo tumor imaging.
Adv Mater
; 26(48): 8174-8, 2014 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-25338710
ABSTRACT
A protease-responsive probe is developed based on a molecular dynamics simulation method for the rational design of the hairpin "turn" structure of peptides. The Förster resonance energy transfer (FRET)-based probe is used for in vivo detection of legumain, a protease overexpressed in inflammation-related carcinogenesis, providing a potential method for early cancer detection and tumor imaging, and helpful information for better understanding legumain's role in tumorigenesis.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Simulação de Dinâmica Molecular
/
Corantes Fluorescentes
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article