Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.

Baker, Scott T; Turgeon, Shane M; Tulgren, Erik D; Wigant, Jeanne; Rahimi, Omeed; Opperman, Karla J; Grill, Brock

Baker, Scott T; Turgeon, Shane M; Tulgren, Erik D; Wigant, Jeanne; Rahimi, Omeed; Opperman, Karla J; Grill, Brock.

Afiliação

Baker ST; Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
Turgeon SM; Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458.
Tulgren ED; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
Wigant J; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
Rahimi O; Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
Opperman KJ; Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458.
Grill B; Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 bgrill@scripps.edu.

Genetics ; 199(1): 151-6, 2015 Jan.

Article em En | MEDLINE | ID: mdl-25339611

ABSTRACT

ABSTRACT

We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway.

Assuntos

Proteínas de Caenorhabditis elegans/genética; Caenorhabditis elegans/genética; Proteínas Quinases JNK Ativadas por Mitógeno/genética; MAP Quinase Quinase 1/genética; Sistema de Sinalização das MAP Quinases; Neurogênese; Animais; Axônios/metabolismo; Caenorhabditis elegans/crescimento & desenvolvimento; Proteínas de Caenorhabditis elegans/metabolismo; Fatores de Troca do Nucleotídeo Guanina/genética; Fatores de Troca do Nucleotídeo Guanina/metabolismo; Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo; MAP Quinase Quinase 1/metabolismo; Sinapses/metabolismo

Palavras-chave

JNK; MAP kinase; RPM-1; axon; synapse

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Caenorhabditis elegans / Sistema de Sinalização das MAP Quinases / Proteínas de Caenorhabditis elegans / MAP Quinase Quinase 1 / Proteínas Quinases JNK Ativadas por Mitógeno / Neurogênese Limite: Animals Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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