The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Durinck, Kaat; Wallaert, Annelynn; Van de Walle, Inge; Van Loocke, Wouter; Volders, Pieter-Jan; Vanhauwaert, Suzanne; Geerdens, Ellen; Benoit, Yves; Van Roy, Nadine; Poppe, Bruce; Soulier, Jean; Cools, Jan; Mestdagh, Pieter; Vandesompele, Jo; Rondou, Pieter; Van Vlierberghe, Pieter; Taghon, Tom; Speleman, Frank

Durinck, Kaat; Wallaert, Annelynn; Van de Walle, Inge; Van Loocke, Wouter; Volders, Pieter-Jan; Vanhauwaert, Suzanne; Geerdens, Ellen; Benoit, Yves; Van Roy, Nadine; Poppe, Bruce; Soulier, Jean; Cools, Jan; Mestdagh, Pieter; Vandesompele, Jo; Rondou, Pieter; Van Vlierberghe, Pieter; Taghon, Tom; Speleman, Frank.

Afiliação

Durinck K; Center for Medical Genetics, Ghent University, Belgium; kaat.durinck@ugent.be franki.speleman@ugent.be.
Wallaert A; Center for Medical Genetics, Ghent University, Belgium;
Van de Walle I; Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium;
Van Loocke W; Center for Medical Genetics, Ghent University, Belgium;
Volders PJ; Center for Medical Genetics, Ghent University, Belgium;
Vanhauwaert S; Center for Medical Genetics, Ghent University, Belgium;
Geerdens E; Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, KU Leuven and Center for the Biology of Disease, VIB, Leuven, Belgium;
Benoit Y; Center for Medical Genetics, Ghent University, Belgium;
Van Roy N; Center for Medical Genetics, Ghent University, Belgium;
Poppe B; Center for Medical Genetics, Ghent University, Belgium;
Soulier J; Genome Rearrangements and Cancer Laboratory, U944 INSERM, University Paris Diderot and Hematology Laboratory, Saint-Louis Hospital, Paris, France.
Cools J; Laboratory for the Molecular Biology of Leukemia, Center for Human Genetics, KU Leuven and Center for the Biology of Disease, VIB, Leuven, Belgium;
Mestdagh P; Center for Medical Genetics, Ghent University, Belgium;
Vandesompele J; Center for Medical Genetics, Ghent University, Belgium;
Rondou P; Center for Medical Genetics, Ghent University, Belgium;
Van Vlierberghe P; Center for Medical Genetics, Ghent University, Belgium;
Taghon T; Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium;
Speleman F; Center for Medical Genetics, Ghent University, Belgium; kaat.durinck@ugent.be franki.speleman@ugent.be.

Haematologica ; 99(12): 1808-16, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25344525

Assuntos

Biomarcadores Tumorais/genética; Mutação/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Leucemia-Linfoma Linfoblástico de Células T Precursoras/patologia; RNA Longo não Codificante/genética; Receptor Notch1/metabolismo; Timócitos/metabolismo; Secretases da Proteína Precursora do Amiloide/antagonistas & inibidores; Secretases da Proteína Precursora do Amiloide/metabolismo; Biomarcadores Tumorais/metabolismo; Western Blotting; Estudos de Casos e Controles; Transformação Celular Neoplásica/patologia; Células Cultivadas; Imunoprecipitação da Cromatina; Estudos de Coortes; Inibidores Enzimáticos/farmacologia; Seguimentos; Perfilação da Expressão Gênica; Humanos; Análise de Sequência com Séries de Oligonucleotídeos; Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamento farmacológico; Prognóstico; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Receptor Notch1/antagonistas & inibidores; Receptor Notch1/genética; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais; Timócitos/citologia; Timócitos/efeitos dos fármacos

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Receptor Notch1 / Leucemia-Linfoma Linfoblástico de Células T Precursoras / Timócitos / RNA Longo não Codificante / Mutação Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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