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Prolactin and natural killer cells: evaluating the neuroendocrine-immune axis in women with primary infertility and recurrent spontaneous abortion.
Triggianese, Paola; Perricone, Carlo; Perricone, Roberto; De Carolis, Caterina.
Afiliação
  • Triggianese P; Department of 'Medicina dei Sistemi', Rheumatology, Allergology and Clinical Immunology, University of Rome Tor Vergata, Rome, Italy.
Am J Reprod Immunol ; 73(1): 56-65, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25345488
ABSTRACT

PROBLEM:

An association between serum prolactin (PRL) and peripheral blood natural killer (NK) cells has been described in healthy women. We explored for the first time the PRL response to the thyrotrophin-releasing hormone (TRH) test and the association between PRL and NK cells in women with reproductive failure.

METHODS:

A total of 130 women [31 primary infertility, 69 recurrent spontaneous abortion (RSA), and 30 fertile women] were evaluated by a TRH test to analyze the following basal PRL (bPRL), peak-time PRL, PRL absolute and relative increase, decline-time PRL. Hyperprolactinaemia (HPRL) was defined as bPRL ≥15 ng/mL. NK cells were characterized by immunophenotyping.

RESULTS:

Significantly higher bPRL levels were found in the infertile women than in controls. Both the infertile and the RSA women showed significantly elevated NK levels. bPRL levels correlated with NK cells in HPRL-infertile women.

CONCLUSIONS:

In patients with HPRL, an association between NK cell and bPRL results. The dynamic test in the infertile women would help in the management of the pregnancy impairment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prolactina / Células Matadoras Naturais / Aborto Habitual / Infertilidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Prolactina / Células Matadoras Naturais / Aborto Habitual / Infertilidade Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2015 Tipo de documento: Article