Rhodium(III)- and iridium(III)-catalyzed C7 alkylation of indolines with diazo compounds.
Chemistry
; 20(52): 17653-7, 2014 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-25359110
ABSTRACT
A Rh(III)-catalyzed procedure for the C7-selective C-H alkylation of various indolines with α-diazo compounds at room temperature is reported. The advantages of this process are 1)â
simple, mild, and pH-neutral reaction conditions, 2)â
broad substrate scope, 3)â
complete regioselectivity, 4)â
no need for an external oxidant, and 5)â
N2 as the sole byproduct. Furthermore, alkylation and bis-alkylation of carbazoles at the C1 and C8 positions have also been developed. More significantly, for the first time, a successful Ir(III)-catalyzed intermolecular insertion of arene C-H bonds into α-diazo compounds is reported.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ródio
/
Compostos Azo
/
Irídio
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article