Chronic myelogenous leukemia, version 1.2015.
J Natl Compr Canc Netw
; 12(11): 1590-610, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25361806
ABSTRACT
Chronic myelogenous leukemia (CML) is usually diagnosed in the chronic phase. Untreated chronic phase CML will eventually progress to advanced phase (accelerated or blast phase) CML. Tyrosine kinase inhibitors (TKIs) have been shown to induce favorable response rates in patients with accelerated and blast phase CML. The addition of TKIs to chemotherapy has also been associated with improved outcomes in patients with blast phase CML. Allogeneic hematopoietic stem cell transplant remains a potentially curative option for patients with advanced phase CML, although treatment with a course of TKIs will be beneficial as a bridge to transplant. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with advanced phase CML.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide de Fase Acelerada
/
Leucemia Mieloide de Fase Crônica
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article