miR-31 promotes proliferation of colon cancer cells by targeting E2F2.
Biotechnol Lett
; 37(3): 523-32, 2015 Mar.
Article
em En
| MEDLINE
| ID: mdl-25362258
ABSTRACT
MicroRNA-31 (miR-31) plays important roles in colon cancer development. However, the underlying mechanism is still not clear. We have explored the functions of miR-31 on proliferation of colon cancer cells as well as the underlying mechanism. E2F2 was identified as a direct target of miR-31. miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. Moreover, in the present study, E2F2 acted as a tumor suppressor in colon cancer by repressing the expression of survivin and regulating the expression of CCNA2, C-MYC, MCM4 and CDK2. A possible mechanism for the function of miR-31 on colon cancer proliferation is presented and indicates that miR-31 might become a target for anti-cancer drug design.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
MicroRNAs
/
Proliferação de Células
/
Células Epiteliais
/
Fator de Transcrição E2F2
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article