Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.

Borcherds, Wade; Theillet, François-Xavier; Katzer, Andrea; Finzel, Ana; Mishall, Katie M; Powell, Anne T; Wu, Hongwei; Manieri, Wanda; Dieterich, Christoph; Selenko, Philipp; Loewer, Alexander; Daughdrill, Gary W

Borcherds, Wade; Theillet, François-Xavier; Katzer, Andrea; Finzel, Ana; Mishall, Katie M; Powell, Anne T; Wu, Hongwei; Manieri, Wanda; Dieterich, Christoph; Selenko, Philipp; Loewer, Alexander; Daughdrill, Gary W.

Afiliação

Borcherds W; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
Theillet FX; In-cell NMR Laboratory, Department of NMR-supported Structural Biology, Leibniz Institute of Molecular Pharmacology (FMP Berlin), Berlin, Germany.
Katzer A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Finzel A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Mishall KM; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
Powell AT; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
Wu H; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.
Manieri W; Drug Discovery Department, Moffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
Dieterich C; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Selenko P; In-cell NMR Laboratory, Department of NMR-supported Structural Biology, Leibniz Institute of Molecular Pharmacology (FMP Berlin), Berlin, Germany.
Loewer A; Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
Daughdrill GW; 1] Department of Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, Florida, USA. [2] Center for Drug Discovery and Innovation, University of South Florida, Tampa, Florida, USA.

Nat Chem Biol ; 10(12): 1000-2, 2014 Dec.

Article em En | MEDLINE | ID: mdl-25362358

Assuntos

Proteínas Intrinsicamente Desordenadas/química; Proteínas Proto-Oncogênicas c-mdm2/química; Transdução de Sinais; Proteína Supressora de Tumor p53/química; Ciclo Celular/genética; Ciclo Celular/efeitos da radiação; Linhagem Celular Tumoral; Dano ao DNA; Escherichia coli/genética; Escherichia coli/metabolismo; Raios gama; Regulação da Expressão Gênica; Humanos; Proteínas Intrinsicamente Desordenadas/genética; Proteínas Intrinsicamente Desordenadas/metabolismo; Modelos Moleculares; Mutação; Dobramento de Proteína; Estrutura Secundária de Proteína; Estrutura Terciária de Proteína; Proteínas Proto-Oncogênicas c-mdm2/genética; Proteínas Proto-Oncogênicas c-mdm2/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína Supressora de Tumor p53 / Proteínas Proto-Oncogênicas c-mdm2 / Proteínas Intrinsicamente Desordenadas Limite: Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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