Grazing incidence angle based sensing approach integrated with fiber-optic Fourier transform infrared (FO-FTIR) spectroscopy for remote and label-free detection of medical device contaminations.
Rev Sci Instrum
; 85(10): 103108, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-25362372
ABSTRACT
Contamination of medical devices has become a critical and prevalent public health safety concern since medical devices are being increasingly used in clinical practices for diagnostics, therapeutics and medical implants. The development of effective sensing methods for real-time detection of pathogenic contamination is needed to prevent and reduce the spread of infections to patients and the healthcare community. In this study, a hollow-core fiber-optic Fourier transform infrared spectroscopy methodology employing a grazing incidence angle based sensing approach (FO-FTIR-GIA) was developed for detection of various biochemical contaminants on medical device surfaces. We demonstrated the sensitivity of FO-FTIR-GIA sensing approach for non-contact and label-free detection of contaminants such as lipopolysaccharide from various surface materials relevant to medical device. The proposed sensing system can detect at a minimum loading concentration of approximately 0.7 µg/cm(2). The FO-FTIR-GIA has the potential for the detection of unwanted pathogen in real time.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Contaminação de Equipamentos
/
Espectroscopia de Infravermelho com Transformada de Fourier
/
Fibras Ópticas
/
Tecnologia de Sensoriamento Remoto
Tipo de estudo:
Diagnostic_studies
/
Incidence_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article