Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Nat Immunol
; 15(12): 1152-61, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25362489
ABSTRACT
The importance of autophagy in the generation of memory CD8(+) T cells in vivo is not well defined. We report here that autophagy was dynamically regulated in virus-specific CD8(+) T cells during acute infection of mice with lymphocytic choriomeningitis virus. In contrast to the current paradigm, autophagy decreased in activated proliferating effector CD8(+) T cells and was then upregulated when the cells stopped dividing just before the contraction phase. Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Diferenciação Celular
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Linfócitos T CD8-Positivos
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Memória Imunológica
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article