Aneurysm wall thickness measurements of experimental aneurysms: in vivo high-field MR imaging versus direct microscopy.
Acta Neurochir Suppl
; 120: 17-20, 2015.
Article
em En
| MEDLINE
| ID: mdl-25366593
ABSTRACT
BACKGROUND:
Thin cerebral aneurysm wall thickness (AWT) is connected to high aneurysm rupture risk. MR imaging of AWT leads to overestimations. The aim of the present study was to quantify MR inaccuracy by comparison with accurate light microscopic measurements.METHODS:
In 13 experimental microsurgical bifurcation aneurysms in rabbits, 3 Tesla (3 T)-MR imaging using contrast-enhanced T1 Flash sequences (resolution 0.4 × 0.4 × 1.5 mm³) was performed. The aneurysms were retrieved immediately after MR acquisition, cut longitudinally, and calibrated photographs were obtained. AWT (dome, neck) and parent vessel thickness (PVT) were measured on the MR images and microscopic photographs by independent investigators. All parameters were statistically compared (Wilcoxon test, Spearman correlation).RESULTS:
AWT and PVT could be imaged and measured in all aneurysms with good quality. Comparison with the "real" light microscopic measurements showed a progressive tendency of MR AWT overestimation with smaller AWT AWT at the dome (0.24 ± 0.06 mm vs. MR 0.30 ± 0.08 mm; p = 0.0078; R = 0.6125), AWT at the neck (0.25 ± 0.07 mm vs. MR 0.29 ± 0.07 mm; p = 0.0469; R = 0.7451), and PVT (0.46 ± 0.06 mm vs. MR 0.48 ± 0.06 mm; p = 0.5; R = 0.8568).CONCLUSION:
In this experimental setting, 3 T-MR imaging of cerebral AWT showed unacceptable inaccuracies only below the image resolution threshold. Theoretically, AWT for clinical usage could be classified in ranges, defined by the maximum image resolution.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aneurisma Intracraniano
/
Artérias Cerebrais
/
Aneurisma Roto
/
Angiografia por Ressonância Magnética
/
Microscopia
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article