Increase of type 2 ryanodine receptors in mouse nucleus accumbens in the development and expression of morphine-induced place preference.
J Pharmacol Sci
; 126(3): 285-90, 2014.
Article
em En
| MEDLINE
| ID: mdl-25367193
ABSTRACT
The present study investigated the effect of ryanodine receptors (RyRs) in the development and expression of morphine-induced conditioned place preference (CPP). Type 2 RyRs (RyRs-2) in the nucleus accumbens (NAcc) significantly increased in morphine-conditioned mice, whereas type 1, 2, and 3 RyRs in the frontal cortex and ventral tegmental area showed no changes. Intracerebroventricular pretreatment with dantrolene, a RyRs antagonist, during the conditioning phase of CPP, dose-dependently inhibited morphine-induced CPP. The expression of morphine-induced CPP was abolished by dantrolene administration before the post-conditioning test. These findings suggest that RyRs-2 in the NAcc participate in the development and expression of morphine-induced CPP.
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Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Condicionamento Psicológico
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
Morfina
/
Transtornos Relacionados ao Uso de Opioides
/
Núcleo Accumbens
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article