Protein and mRNA expression of notch pathway components in operable tumors of patients with laryngeal cancer.

Krikelis, Dimitrios; Kotoula, Vassiliki; Bobos, Mattheos; Fountzilas, Elena; Markou, Konstantinos; Karasmanis, Ilias; Angouridakis, Nikolaos; Vlachtsis, Konstantinos; Kalogeras, Konstantine T; Nikolaou, Angelos; Fountzilas, George

Krikelis, Dimitrios; Kotoula, Vassiliki; Bobos, Mattheos; Fountzilas, Elena; Markou, Konstantinos; Karasmanis, Ilias; Angouridakis, Nikolaos; Vlachtsis, Konstantinos; Kalogeras, Konstantine T; Nikolaou, Angelos; Fountzilas, George.

Afiliação

Krikelis D; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece dkrikelis@gmail.com.
Kotoula V; Department of Pathology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Bobos M; Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Fountzilas E; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Markou K; First Department of Otorhinolaryngology, AHEPA Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Karasmanis I; ENT Department, G. Papanikolaou General Hospital, Thessaloniki, Greece.
Angouridakis N; First Department of Otorhinolaryngology, AHEPA Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Vlachtsis K; First Department of Otorhinolaryngology, AHEPA Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
Kalogeras KT; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece Translational Research Section, Hellenic Cooperative Oncology Group, Data Office, Athens, Greece.
Nikolaou A; ENT Department, G. Papanikolaou General Hospital, Thessaloniki, Greece.
Fountzilas G; Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.

Anticancer Res ; 34(11): 6495-503, 2014 Nov.

Article em En | MEDLINE | ID: mdl-25368251

Assuntos

Proteínas de Ligação ao Cálcio/genética; Proteínas de Ligação ao Cálcio/metabolismo; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Neoplasias Laríngeas/genética; Neoplasias Laríngeas/metabolismo; Proteínas de Membrana/genética; Proteínas de Membrana/metabolismo; Receptores Notch/genética; Receptores Notch/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Biomarcadores Tumorais/genética; Biomarcadores Tumorais/metabolismo; Carcinoma de Células Escamosas/mortalidade; Carcinoma de Células Escamosas/cirurgia; Núcleo Celular/metabolismo; Citoplasma/metabolismo; Feminino; Seguimentos; Humanos; Técnicas Imunoenzimáticas; Proteína Jagged-1; Neoplasias Laríngeas/mortalidade; Neoplasias Laríngeas/cirurgia; Masculino; Pessoa de Meia-Idade; Gradação de Tumores; Estadiamento de Neoplasias; Prognóstico; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Proteínas Serrate-Jagged; Taxa de Sobrevida

Palavras-chave

Jagged1; Laryngeal cancer; Notch; immunohistochemistry; mRNA expression; multivariate analysis; prognostic value

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Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Carcinoma de Células Escamosas / Neoplasias Laríngeas / Peptídeos e Proteínas de Sinalização Intercelular / Receptores Notch / Proteínas de Membrana Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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