Design, structure-activity relationship, and in vivo characterization of the development candidate NVP-HSP990.
J Med Chem
; 57(21): 9124-9, 2014 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-25368984
ABSTRACT
Utilizing structure-based drug design, a novel dihydropyridopyrimidinone series which exhibited potent Hsp90 inhibition, good pharmacokinetics upon oral administration, and an excellent pharmacokinetic/pharmacodynamic relationship in vivo was developed from a commercial hit. The exploration of this series led to the selection of NVP-HSP990 as a development candidate.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Pirimidinas
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article