Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1.

Ono, Manabu; Ohkouchi, Shinya; Kanehira, Masahiko; Tode, Naoki; Kobayashi, Makoto; Ebina, Masahito; Nukiwa, Toshihiro; Irokawa, Toshiya; Ogawa, Hiromasa; Akaike, Takaaki; Okada, Yoshinori; Kurosawa, Hajime; Kikuchi, Toshiaki; Ichinose, Masakazu

Ono, Manabu; Ohkouchi, Shinya; Kanehira, Masahiko; Tode, Naoki; Kobayashi, Makoto; Ebina, Masahito; Nukiwa, Toshihiro; Irokawa, Toshiya; Ogawa, Hiromasa; Akaike, Takaaki; Okada, Yoshinori; Kurosawa, Hajime; Kikuchi, Toshiaki; Ichinose, Masakazu.

Afiliação

Ono M; Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ohkouchi S; 1] Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan [2] Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kanehira M; 1] Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan [2] Department of Hematology and Rheumatology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Tode N; Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kobayashi M; Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ebina M; Pulmonary Center, Tohoku Pharmaceutical University Hospital, Sendai, Japan.
Nukiwa T; Japan Anti-tuberculosis Association, Tokyo, Japan.
Irokawa T; Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ogawa H; Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Akaike T; Department of Environmental Health Sciences and Molecular Toxicology, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Okada Y; Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Kurosawa H; Department of Occupational Health, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Kikuchi T; Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.
Ichinose M; Department of Respiratory Medicine, Graduate School of Medicine, Tohoku University, Sendai, Japan.

Mol Ther ; 23(3): 549-60, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25373521

Assuntos

Células Epiteliais/metabolismo; Fibroblastos/metabolismo; Glicoproteínas/metabolismo; Fibrose Pulmonar Idiopática/genética; Células-Tronco Mesenquimais/metabolismo; Alvéolos Pulmonares/metabolismo; Animais; Bleomicina; Comunicação Celular; Citomegalovirus/genética; Estresse do Retículo Endoplasmático/genética; Células Epiteliais/patologia; Feminino; Fibroblastos/patologia; Regulação da Expressão Gênica; Vetores Genéticos; Glicoproteínas/genética; Humanos; Fibrose Pulmonar Idiopática/induzido quimicamente; Fibrose Pulmonar Idiopática/metabolismo; Fibrose Pulmonar Idiopática/patologia; Canais Iônicos/genética; Canais Iônicos/metabolismo; Células-Tronco Mesenquimais/patologia; Camundongos Endogâmicos C57BL; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/metabolismo; Estresse Oxidativo; Plasmídeos/química; Plasmídeos/metabolismo; Alvéolos Pulmonares/patologia; Transdução de Sinais; Transfecção; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo; Proteína Desacopladora 2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alvéolos Pulmonares / Glicoproteínas / Células Epiteliais / Fibrose Pulmonar Idiopática / Células-Tronco Mesenquimais / Fibroblastos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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