Antivirulence properties of an antifreeze protein.
Cell Rep
; 9(2): 417-24, 2014 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-25373896
ABSTRACT
As microbial drug-resistance increases, there is a critical need for new classes of compounds to combat infectious diseases. The Ixodes scapularis tick antifreeze glycoprotein, IAFGP, functions as an antivirulence agent against diverse bacteria, including methicillin-resistant Staphylococcus aureus. Recombinant IAFGP and a peptide, P1, derived from this protein bind to microbes and alter biofilm formation. Transgenic iafgp-expressing flies and mice challenged with bacteria, as well as wild-type animals administered P1, were resistant to infection, septic shock, or biofilm development on implanted catheter tubing. These data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Insetos
/
Proteínas Anticongelantes
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Staphylococcus aureus Resistente à Meticilina
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Antibacterianos
Limite:
Animals
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article