N-Boc deprotection and isolation method for water-soluble zwitterionic compounds.
J Org Chem
; 79(23): 11792-6, 2014 Dec 05.
Article
em En
| MEDLINE
| ID: mdl-25376704
ABSTRACT
A highly efficient TMSI-mediated deprotection and direct isolation method to obtain zwitterionic compounds from the corresponding N-Boc derivatives has been developed. This method has been demonstrated in the final deprotection/isolation of the ß-lactamase inhibitor MK-7655 as a part of its manufacturing process. Further application of this process toward other zwitterionic compounds, such as dipeptides and tripeptides, has been successfully developed. Furthermore, a catalytic version of this transformation has been demonstrated in the presence of BSA or BSTFA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Trimetilsilil
/
Dipeptídeos
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Compostos Azabicíclicos
/
Inibidores de beta-Lactamases
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article