Aha1 can act as an autonomous chaperone to prevent aggregation of stressed proteins.

Tripathi, Vishwadeepak; Darnauer, Stefanie; Hartwig, Nadine R; Obermann, Wolfgang M J

Tripathi, Vishwadeepak; Darnauer, Stefanie; Hartwig, Nadine R; Obermann, Wolfgang M J.

Afiliação

Tripathi V; From the Department of Cardiovascular Physiology, Ruhr-University Bochum, 44801 Bochum, Germany.
Darnauer S; From the Department of Cardiovascular Physiology, Ruhr-University Bochum, 44801 Bochum, Germany.
Hartwig NR; From the Department of Cardiovascular Physiology, Ruhr-University Bochum, 44801 Bochum, Germany.
Obermann WM; From the Department of Cardiovascular Physiology, Ruhr-University Bochum, 44801 Bochum, Germany Wolfgang.Obermann@rub.de.

J Biol Chem ; 289(52): 36220-8, 2014 Dec 26.

Article em En | MEDLINE | ID: mdl-25378400

Assuntos

Chaperonas Moleculares/fisiologia; Agregação Patológica de Proteínas/metabolismo; Animais; Células HEK293; Proteínas de Choque Térmico HSP90/metabolismo; Humanos; Luciferases de Vaga-Lume/química; Macaca mulatta; Camundongos; Chaperonas Moleculares/química; Ligação Proteica; Redobramento de Proteína; Proteólise; Tiossulfato Sulfurtransferase/química; Ubiquitinação

Palavras-chave

ATPase; Activator of Hsp90 ATPase (Aha1); Heat Shock Protein 90 (Hsp90); Molecular Chaperone; Protein Aggregation; Protein Folding

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Chaperonas Moleculares / Agregação Patológica de Proteínas Limite: Animals / Humans Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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