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Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging.
Roberts, Jason D; Dewland, Thomas A; Longoria, James; Fitzpatrick, Annette L; Ziv, Elad; Hu, Donglei; Lin, Jue; Glidden, David V; Psaty, Bruce M; Burchard, Esteban G; Blackburn, Elizabeth H; Olgin, Jeffrey E; Heckbert, Susan R; Marcus, Gregory M.
Afiliação
  • Roberts JD; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Dewland TA; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Longoria J; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Fitzpatrick AL; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Ziv E; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Hu D; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Lin J; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Glidden DV; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Psaty BM; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Burchard EG; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Blackburn EH; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Olgin JE; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Heckbert SR; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
  • Marcus GM; From the Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine (J.D.R., T.A.D., J.E.O., G.M.M.), Institute of Human Genetics and Department of Medicine (E.Z., D.H.), Department of Biochemistry and Biophysics (J.L., E.H.B.), Department of Epidemiology and Biostatistics
Circ Arrhythm Electrophysiol ; 7(6): 1026-32, 2014 Dec.
Article em En | MEDLINE | ID: mdl-25381796
ABSTRACT

BACKGROUND:

Advanced age is the most important risk factor for atrial fibrillation (AF); however, the mechanism remains unknown. Telomeres, regions of DNA that shorten with cell division, are considered reliable markers of biological aging. We sought to examine the association between leukocyte telomere length (LTL) and incident AF in a large population-based cohort using direct LTL measurements and genetic data. To further explore our findings, we compared atrial cell telomere length and LTL in cardiac surgery patients. METHODS AND

RESULTS:

Mean LTL and the TERT rs2736100 single nucleotide polymorphism were assessed as predictors of incident AF in the Cardiovascular Health Study (CHS). Among the surgical patients, within subject comparison of atrial cell telomere length versus LTL was assessed. Among 1639 CHS participants, we observed no relationship between mean LTL and incident AF before and after adjustment for potential confounders (adjusted hazard ratio, 1.09; 95% confidence interval 0.92-1.29; P=0.299); chronologic age remained strongly associated with AF in the same model. No association was observed between the TERT rs2736100 single nucleotide polymorphism and incident AF (adjusted hazard ratio 0.95; 95% confidence interval 0.88-1.04; P=0.265). In 35 cardiac surgery patients (26 with AF), atrial cell telomere length was longer than LTL (1.19 ± 0.20 versus 1.02 ± 0.25 [T/S ratio], P<0.001), a finding that remained consistent within the AF subgroup.

CONCLUSIONS:

Our study revealed no evidence of an association between LTL and incident AF and no evidence of relative atrial cell telomere shortening in AF. Chronological aging independent of biological markers of aging is the primary risk factor for AF.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Envelhecimento / Telômero / Senescência Celular / Telomerase / Polimorfismo de Nucleotídeo Único / Leucócitos Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial / Envelhecimento / Telômero / Senescência Celular / Telomerase / Polimorfismo de Nucleotídeo Único / Leucócitos Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2014 Tipo de documento: Article