The small-molecule inhibitor selectivity between IKK&#945; and IKKß kinases in NF-&#954;B signaling pathway.

Tian, Feifei; Zhou, Peng; Kang, Wenyuan; Luo, Li; Fan, Xia; Yan, Jun; Liang, Huaping

The small-molecule inhibitor selectivity between IKKα and IKKß kinases in NF-κB signaling pathway.

Tian, Feifei; Zhou, Peng; Kang, Wenyuan; Luo, Li; Fan, Xia; Yan, Jun; Liang, Huaping.

Afiliação

Tian F; a State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital , Third Military Medical University , Chongqing , China .
Zhou P; b School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China , and.
Kang W; c Center of Bioinformatics (COBI), School of Life Science and Technology , University of Electronic Science and Technology of China (UESTC) , Chengdu , China.
Luo L; b School of Life Science and Engineering , Southwest Jiaotong University , Chengdu , China , and.
Fan X; a State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital , Third Military Medical University , Chongqing , China .
Yan J; a State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital , Third Military Medical University , Chongqing , China .
Liang H; a State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital , Third Military Medical University , Chongqing , China .

J Recept Signal Transduct Res ; 35(4): 307-18, 2015.

Article em En | MEDLINE | ID: mdl-25386663

Assuntos

Quinase I-kappa B/antagonistas & inibidores; NF-kappa B/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Sequência de Aminoácidos; Domínio Catalítico; Humanos; Quinase I-kappa B/química; Quinase I-kappa B/genética; Modelos Moleculares; Simulação de Dinâmica Molecular; Dados de Sequência Molecular; Inibidores de Proteínas Quinases/química; Estrutura Terciária de Proteína; Relação Quantitativa Estrutura-Atividade; Teoria Quântica; Transdução de Sinais/efeitos dos fármacos; Homologia Estrutural de Proteína

Palavras-chave

IKKα/IKKß; NF-κB; inflammation; ligand selectivity; small-molecule inhibitor

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: NF-kappa B / Inibidores de Proteínas Quinases / Quinase I-kappa B Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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