Intradermal inactivated poliovirus vaccine: a preclinical dose-finding study.
J Infect Dis
; 211(9): 1447-50, 2015 May 01.
Article
em En
| MEDLINE
| ID: mdl-25391313
ABSTRACT
Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability of fractional doses of inactivated poliovirus vaccine (IPV) delivered intradermally to induce levels of serum poliovirus-neutralizing antibodies similar to immunization through the intramuscular route. Immunogenicity of fractional doses of IPV was studied by comparing intramuscular and intradermal immunization of Wistar rats using NanoPass MicronJet600 microneedles. Intradermal delivery of partial vaccine doses induced antibodies at titers comparable to those after immunization with full human dose delivered intramuscularly. The results suggest that intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacina Antipólio de Vírus Inativado
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article