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Treatment of elderly patients with acute myeloid leukemia adjusted for performance status and presence of comorbidities: a Polish Adult Leukemia Group study.
Budziszewska, Bozena Katarzyna; Pluta, Agnieszka; Sulek, Kazimierz; Wierzbowska, Agnieszka; Robak, Tadeusz; Giebel, Sebastian; Holowiecka-Goral, Aleksandra; Sawicki, Waldemar; Ejduk, Anna; Patkowska, Elzbieta; Manko, Joanna; Gajkowska-Kulik, Justyna; Piszcz, Jaroslaw; Mordak-Domagala, Monika; Madry, Krzysztof; Holowiecki, Jerzy; Kyrcz-Krzemien, Slawomira; Nowakowska-Domagala, Maria; Dmoszynska, Anna; Calbecka, Malgorzata; Kloczko, Janusz; Wiktor Jedrzejczak, Wieslaw; Lange, Andrzej; Razny, Malgorzata; Bilinski, Przemyslaw; Warzocha, Krzysztof; Lech-Maranda, Ewa.
Afiliação
  • Budziszewska BK; a Hematology Department, Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
  • Pluta A; b Center of Postgraduate Medical Education , Warsaw , Poland.
  • Sulek K; c Hematology Department, Medical University of Lodz , Lodz , Poland.
  • Wierzbowska A; d Hematology Department, Military Medical Institute , Warsaw , Poland.
  • Robak T; c Hematology Department, Medical University of Lodz , Lodz , Poland.
  • Giebel S; c Hematology Department, Medical University of Lodz , Lodz , Poland.
  • Holowiecka-Goral A; e Department of Bone Marrow Transplantation , Comprehensive Cancer Center, M. Sklodowska-Curie Memorial Institute , Gliwice , Poland.
  • Sawicki W; a Hematology Department, Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
  • Ejduk A; d Hematology Department, Military Medical Institute , Warsaw , Poland.
  • Patkowska E; a Hematology Department, Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
  • Manko J; a Hematology Department, Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
  • Gajkowska-Kulik J; b Center of Postgraduate Medical Education , Warsaw , Poland.
  • Piszcz J; f Hematology Department, Medical University of Lublin , Lublin , Poland.
  • Mordak-Domagala M; g Hematology Department, Nicolaus Copernicus Hospital , Torun , Poland.
  • Madry K; h Hematology Department, Medical University of Bialystok , Bialystok , Poland.
  • Holowiecki J; i Lower Silesian Centrum for Cellular Transplantation , Wroclaw , Poland.
  • Kyrcz-Krzemien S; j Hematology and Oncology Department, Warsaw Medical University , Warsaw , Poland.
  • Nowakowska-Domagala M; e Department of Bone Marrow Transplantation , Comprehensive Cancer Center, M. Sklodowska-Curie Memorial Institute , Gliwice , Poland.
  • Dmoszynska A; k Hematology Department and BMT , Medical University of Silesia , Katowice , Poland.
  • Calbecka M; l Hematology Department, Center of Oncology , Kielce , Poland.
  • Kloczko J; f Hematology Department, Medical University of Lublin , Lublin , Poland.
  • Wiktor Jedrzejczak W; g Hematology Department, Nicolaus Copernicus Hospital , Torun , Poland.
  • Lange A; h Hematology Department, Medical University of Bialystok , Bialystok , Poland.
  • Razny M; j Hematology and Oncology Department, Warsaw Medical University , Warsaw , Poland.
  • Bilinski P; i Lower Silesian Centrum for Cellular Transplantation , Wroclaw , Poland.
  • Warzocha K; m Hematology Department, Rydygier Memorial Hospital , Krakow , Poland.
  • Lech-Maranda E; a Hematology Department, Institute of Hematology and Transfusion Medicine , Warsaw , Poland.
Leuk Lymphoma ; 56(8): 2331-8, 2015.
Article em En | MEDLINE | ID: mdl-25393675
ABSTRACT
This prospective study estimated outcomes in 509 elderly patients with acute myeloid leukemia (AML) with different treatment approaches depending on Eastern Cooperative Oncology Group (ECOG) performance status and Charlson Comorbidity Index (CCI). Patients were stratified into fit (ECOG 0-2 and CCI 0-2) or frail (ECOG>2 and/or CCI>2) groups. Fit patients with CCI 0 received intensive chemotherapy whilst reduced-intensive chemotherapy (R-IC) was given to those with CCI 1-2. Frail patients received best supportive therapy. Fit patients presented a longer overall survival (OS) than frail subjects, but 8-week mortality rates were similar. The complete response (CR) rate between fit CCI 0 and CCI 1-2 subgroups was significantly different. Both of the fit subgroups showed similar 8-week mortality rates and OS probabilities. Allocating fit patients with CCI 1-2 to R-IC enabled an increase in the group of elderly patients who could be treated with the intention of inducing remission.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2015 Tipo de documento: Article