Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment.

Venkatraman, Ganesh; Benesch, Matthew G K; Tang, Xiaoyun; Dewald, Jay; McMullen, Todd P W; Brindley, David N

Venkatraman, Ganesh; Benesch, Matthew G K; Tang, Xiaoyun; Dewald, Jay; McMullen, Todd P W; Brindley, David N.

Afiliação

Venkatraman G; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada.
Benesch MG; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada.
Tang X; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada.
Dewald J; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada.
McMullen TP; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada.
Brindley DN; *Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada; and Department of Surgery, University of Alberta, WC Mackenzie Health Science Centre, Edmonton, Alberta, Canada david.brindley@ualberta.ca.

FASEB J ; 29(3): 772-85, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25398768

Assuntos

Biomarcadores/metabolismo; Neoplasias da Mama/patologia; Doxorrubicina/farmacologia; Resistencia a Medicamentos Antineoplásicos/genética; Lisofosfolipídeos/metabolismo; Fator 2 Relacionado a NF-E2/química; Estresse Oxidativo/genética; Animais; Antibióticos Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Western Blotting; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Modelos Animais de Doenças; Feminino; Humanos; Técnicas Imunoenzimáticas; Camundongos; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; RNA Mensageiro/genética; Reação em Cadeia da Polimerase em Tempo Real; Receptores de Ácidos Lisofosfatídicos/metabolismo; Reação em Cadeia da Polimerase Via Transcriptase Reversa; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

autotaxin; autotaxin inhibitors; breast cancer; chemoresistance; doxorubicin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Lisofosfolipídeos / Biomarcadores / Doxorrubicina / Estresse Oxidativo / Resistencia a Medicamentos Antineoplásicos / Fator 2 Relacionado a NF-E2 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2015 Tipo de documento: Article

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