Physical activity and risk of bleeding in elderly patients taking anticoagulants.
J Thromb Haemost
; 13(2): 197-205, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25403550
ABSTRACT
BACKGROUND:
Although the possibility of bleeding during anticoagulant treatment may limit patients from taking part in physical activity, the association between physical activity and anticoagulation-related bleeding is uncertain.OBJECTIVES:
To determine whether physical activity is associated with bleeding in elderly patients taking anticoagulants. PATIENTS/METHODS:
In a prospective multicenter cohort study of 988 patients aged ≥ 65 years receiving anticoagulants for venous thromboembolism, we assessed patients' self-reported physical activity level. The primary outcome was the time to a first major bleeding, defined as fatal bleeding, symptomatic bleeding in a critical site, or bleeding causing a fall in hemoglobin or leading to transfusions. The secondary outcome was the time to a first clinically relevant non-major bleeding. We examined the association between physical activity level and time to a first bleeding by using competing risk regression, accounting for death as a competing event. We adjusted for known bleeding risk factors and anticoagulation as a time-varying covariate.RESULTS:
During a mean follow-up of 22 months, patients with a low, moderate, and high physical activity level had an incidence of major bleeding of 11.6, 6.3, and 3.1 events per 100 patient-years and an incidence of clinically relevant non-major bleeding of 14.0, 10.3, and 7.7 events per 100 patient-years, respectively. A high physical activity level was significantly associated with a lower risk of major bleeding (adjusted sub-hazard ratio 0.40, 95% confidence interval 0.22-0.72). There was no association between physical activity and non-major bleeding.CONCLUSIONS:
A high level of physical activity is associated with a decreased risk of major bleeding in elderly patients receiving anticoagulant therapy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tromboembolia Venosa
/
Hemorragia
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Atividade Motora
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Anticoagulantes
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article