[Research progress on the relationship between SLCO1B1 gene and neonatal jaundice].
Zhongguo Dang Dai Er Ke Za Zhi
; 16(11): 1183-7, 2014 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-25406570
ABSTRACT
Organic anion transporter 2 (OATP2) is an uptake transporter located on the basolateral membrane of human hepatocytes. It mediates the transportation of various organic solutes including bilirubin and impacts bilirubin metabolism. It is encoded by the gene of solute carrier organic anion transporter family member 1B1 and the gene variants that inhibit hepatic bilirubin uptake function may reduce the normal functional level of bilirubin elimination and result in neonatal hyperbilirubinemia. In recent years, some studies have indicated that variants of SLCO1B1 are associated with neonatal jaundice. This article reviews the research advance in SLCO1B1 with respect to the structure and function and the relationship between SLCO1B1 mutations and neonatal jaundice.
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Base de dados:
MEDLINE
Assunto principal:
Transportadores de Ânions Orgânicos
/
Icterícia Neonatal
Limite:
Humans
/
Newborn
Idioma:
Zh
Ano de publicação:
2014
Tipo de documento:
Article