Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.

Thomsen, Gretchen M; Gowing, Genevieve; Latter, Jessica; Chen, Maximus; Vit, Jean-Philippe; Staggenborg, Kevin; Avalos, Pablo; Alkaslasi, Mor; Ferraiuolo, Laura; Likhite, Shibi; Kaspar, Brian K; Svendsen, Clive N

Thomsen, Gretchen M; Gowing, Genevieve; Latter, Jessica; Chen, Maximus; Vit, Jean-Philippe; Staggenborg, Kevin; Avalos, Pablo; Alkaslasi, Mor; Ferraiuolo, Laura; Likhite, Shibi; Kaspar, Brian K; Svendsen, Clive N.

Afiliação

Thomsen GM; Board of Governors Regenerative Medicine Institute.
Gowing G; Board of Governors Regenerative Medicine Institute.
Latter J; Board of Governors Regenerative Medicine Institute.
Chen M; Board of Governors Regenerative Medicine Institute.
Vit JP; Department of Biomedical Sciences, and Biobehavioral Research Core, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Staggenborg K; Board of Governors Regenerative Medicine Institute.
Avalos P; Board of Governors Regenerative Medicine Institute.
Alkaslasi M; Board of Governors Regenerative Medicine Institute.
Ferraiuolo L; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, and.
Likhite S; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, and.
Kaspar BK; Center for Gene Therapy, Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205, and Department of Neuroscience, Ohio State University, Columbus, Ohio 43210.
Svendsen CN; Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, and Clive.Svendsen@cshs.org.

J Neurosci ; 34(47): 15587-600, 2014 Nov 19.

Article em En | MEDLINE | ID: mdl-25411487

Assuntos

Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/patologia; Córtex Motor/enzimologia; Córtex Motor/patologia; Superóxido Dismutase/genética; Superóxido Dismutase/fisiologia; Esclerose Lateral Amiotrófica/mortalidade; Animais; Morte Celular/efeitos dos fármacos; Feminino; Técnicas de Silenciamento de Genes; Herpesvirus Suídeo 1/genética; Humanos; Masculino; Camundongos; Junção Neuromuscular/efeitos dos fármacos; Neurônios/patologia; Ratos; Ratos Sprague-Dawley; Ratos Transgênicos; Superóxido Dismutase-1; Transfecção

Palavras-chave

ALS; RNAi; SOD1; amyotrophic lateral sclerosis; motor neuron disease; neurodegenerative disorder

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Superóxido Dismutase / Esclerose Lateral Amiotrófica / Córtex Motor Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2014 Tipo de documento: Article

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